GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BLCA | cis | rs344081 | 1 | rs2874491 | chr3:156649111 | LEKR1 | chr3:156544076-156763918:+ | -0.45 | -6.22 | 1.29E-9 | Bone mineral density |
| BLCA | cis | rs9815354 | 1 | rs28755797 | chr3:41774446 | ULK4 | chr3:41288091-42003660:- | 0.64 | 9.46 | 3.23E-19 | Diastolic blood pressure |
| BLCA | cis | rs7714584 | 1 | rs2880791 | chr5:150267376 | LOC134466 | chr5:150310000-150326146:- | 0.47 | 6.24 | 1.17E-9 | Crohn's disease |
| BLCA | cis | rs4075511 | 1 | rs2881020 | chr2:18233271 | KCNS3 | chr2:18059114-18114224:+ | 0.25 | 4.08 | 5.42E-5 | Temperament (bipolar disorder) |
| BLCA | cis | rs10935120 | 1 | rs2887797 | chr3:134202506 | ANAPC13 | chr3:134196547-134204865:- | 0.51 | 8.15 | 5.2E-15 | Height |
| BLCA | cis | rs10935120 | 1 | rs2887797 | chr3:134202506 | CEP63 | chr3:134204575-134293852:+ | 0.26 | 4.46 | 1.06E-5 | Height |
| BLCA | cis | rs2888674 | 1 | rs2888674 | chr7:150510915 | TMEM176A | chr7:150497854-150502208:+ | 0.17 | 4.48 | 1.01E-5 | Forced expiratory volume in 1 second (environmental interaction) |
| BLCA | cis | rs2404602 | 1 | rs2896954 | chr15:76851692 | SCAPER | chr15:76640529-77197744:- | -0.22 | -4.72 | 3.34E-6 | Blood metabolite levels |
| BLCA | cis | rs9309473 | 1 | rs2901438 | chr2:73665656 | ALMS1P | chr2:73872046-73912692:+ | 0.4 | 5.95 | 6.22E-9 | Metabolite levels |
| BLCA | cis | rs2905426 | 1 | rs2905425 | chr19:19475717 | YJEFN3 | chr19:19639720-19648393:+ | 0.22 | 4.42 | 1.29E-5 | Schizophrenia |
| BLCA | cis | rs2905426 | 1 | rs2916068 | chr19:19516433 | YJEFN3 | chr19:19639720-19648393:+ | -0.22 | -4.43 | 1.22E-5 | Schizophrenia |
| BLCA | cis | rs2294008 | 1 | rs2920292 | chr8:143765699 | LY6D | chr8:143866298-143868008:- | 0.22 | 4.81 | 2.21E-6 | Gastric adenocarcinoma (histologically verified);Non-cardia gastric cancer;Gastric cancer;Duodenal ulcer;Bladder cancer |
| BLCA | cis | rs2294008 | 1 | rs2920292 | chr8:143765699 | PSCA | chr8:143761875-143764142:+ | 0.52 | 16.1 | 6.5E-45 | Gastric adenocarcinoma (histologically verified);Non-cardia gastric cancer;Gastric cancer;Duodenal ulcer;Bladder cancer |
| BLCA | cis | rs2294008 | 1 | rs2920293 | chr8:143765414 | LY6D | chr8:143866298-143868008:- | 0.23 | 4.84 | 1.85E-6 | Gastric adenocarcinoma (histologically verified);Non-cardia gastric cancer;Gastric cancer;Duodenal ulcer;Bladder cancer |
| BLCA | cis | rs2294008 | 1 | rs2920293 | chr8:143765414 | PSCA | chr8:143761875-143764142:+ | 0.52 | 16.16 | 3.53E-45 | Gastric adenocarcinoma (histologically verified);Non-cardia gastric cancer;Gastric cancer;Duodenal ulcer;Bladder cancer |